Posted by farshad on May 12, 2019, at 12:21:12
In reply to Re: How can I block Cortisol?, posted by Lamdage22 on May 12, 2019, at 10:14:38
> I farshad,
>
> did you get any relief?I'm still on the CRHR1 I know that is my issue- there are two I drugs found to decrease CRHR1 in the amygdala (lithium carbonate,valproic acid) and I have both them in my possession, but I stumbled upon another issue. Over the years my health has deteriorated due to stress making drugs unable to work somehow. I'm not sure the exact cause but I think it has to do with my metabolism is very low. So when I take any drugs they just pass trough me zero effect. That´s why I have ordered Thyroid hormone (t4, didnt find t3) in order to increase my metabolism hoping it will help and I hope it gets absorbed.. also I order progesterone capsules synthetic, Progesterone is a weak but significant agonist of the pregnane X receptor (PXR), and has been found to induce several hepatic cytochrome P450 enzymes, such as CYP3A4, especially when concentrations are high , progesterone may have the potential to accelerate the metabolism of various medications. But then Again if I have trouble with drug absorption will they even work..?......
https://en.wikipedia.org/wiki/Metabolism
But I KNOW for sure CRHR1 in excess levels is my issue in the Amygdala ,and hippocampus perhaps.
in the amygdala, known as the almond core, anxiety and fear are activated in tiny fractions of a second by the stimulus of unconscious and imperceptible, fast as light flash-thoughts.The almond core, consisting of a small almond-shaped accumulation of neurons, has the characteristic and ability to put the entire organism of the human being into a highly sensitive alert-state and to cause a tension of anxiety or fear. The almond core cooperates with another factor of the nearby brain centre, namely the hippocampus, in which memories, living-experiences, situations and experiences are stored like in an archive.I also have a mutation in LMO 1 and LMO 3. I did research on LMO3 and found this: https://www.ncbi.nlm.nih.gov/pubmed/29609111 '' These results suggest that Lmo3 promotes anxiety-like behavior specifically in the BLA, possibly by altering Crhr1 expression. This study is the first to support a role for Lmo3 in anxiety-like behavior.'' On wiki it says '' LMO3 interacts with the tumor suppressor p53 and regulates its function'' Weird that a tumor surpressor gene also increases anxiety in the amygdala..... But valproic acid also decreases this gene.
Then there are these two CRHR1-IT1 (CRHR1 intronic transcript 1) & MGC57346-CRHR1 which I never found out are. but valproic acid decreases one of them so I supposed it decreases the other too which is good....
Looking back on this thread, the cortisol herbs did have any effect but not as much as I am making it out to be, I felt a little relief and it was huge on me because my anxiety was decreased but it was STILL VERY MUCH THERE.
My last resort if these dont work thyroid hormone or prog capsule are antibiotics/antibacterials and anti-inflammatory drugs, hopefully they are absorbed differently.
poster:farshad
thread:1097352
URL: http://www.dr-bob.org/babble/20190206/msgs/1104384.html