Posted by mtom on January 14, 2019, at 10:54:37
In reply to Re: How can ADs increasing norepinephrine help anxiety, posted by bleauberry on January 14, 2019, at 9:44:30
Interesting. Yet Mirtazpine is often prescribed off-label to treat anxiety along with depression, and there are many research reports (and anecdotal ones) attributing this effect to it. SSRIs increase my anxiety. Mirtazpine seems to stimulate some SSRI receptors and block others as far as I can figure out (mode of action is very hypothetical and complex). Perhaps it is the blocking of some Serotonin receptors that causes decrease in anxiety?
> The norepinephrine receptors will tend to adapt to the increased amount of norepinephrine. They are genetically programmed for a certain amount. If there is more than that amount, they will try what they can to adjust to that. One way is by becoming less sensitive to norepinephrine. So when that adjustment happens, and there is less sensitivity to norepinephrine, that is the point where anxiety goes down. But that takes a few weeks or even months to happen, and may not happen at all in some people.
>
> What I got from that med was a mixed pro-anxiety and anti-anxiety at the same time! The antihistamine part of it was anti anxiety, the serotonin blocking was anti anxiety, but the norepinephrine part was pro anxiety, and it was a bizarre thing to feel all of that at the same time.
poster:mtom
thread:1102698
URL: http://www.dr-bob.org/babble/20181024/msgs/1102781.html