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Low dose Marplan + Nardil full dose - why SS?

Posted by PeterMartin on August 6, 2018, at 21:39:03

Why would adding a small dose of Marplan (10/20mg) to a normal dose of Nardil be a serious risk for Serotonin Syndrome or hypertensive crisis?

Many people combine Nardil/Marplan with Lithium which is known to increase Serotonin in the brain. I don't understand why a small dose of Marplan added to Nardil would be more risky. The hope being that it sparks Nardil to work.

I understand why Parnate + another MAOi would be extremely risky but Nardil/Marplan are both hyrdrazine based.




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