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Re: Switching from Abililfy to Saphris. » Robert_Burton_1621

Posted by SLS on July 15, 2018, at 8:20:48

In reply to Re: Switching from Abililfy to Saphris. » SLS, posted by Robert_Burton_1621 on July 15, 2018, at 0:05:30

Hi R_B


> As it happens, Scott, I can myself confirm the efficacy of Ed's suggestion. When on effexor some years ago, I found no extra benefit in increasing beyond 75mg - 150mg. My psychiatrist (not well-versed in psychopharmacology: when effexor pooped-out, he advised there were no further strategies for me! MAOIs far too dangerous, etc. etc.) advised, however, to keep pushing. I was on over 375mg and developed restless leg syndrome and agitation as a result. I had an excellent response to the lower doses for eight weeks(when the supposed NRI action had not kicked-in). But it pooped-out. This has been my experience with any SRI which worked: quite rapid improvement (very noticeable just a few days after first dose), but inevitable poop-out.
>
> I suppose you'd already be familiar with the strategey of adding mirtazapine to effexor. I tried this without any benefit at all. M is pretty much just an extremely powerful H1 antagonist.
>
> All the best. Sorry to hear the vortioxetine didn't agree with you (my experience was just the same).


Thanks for your input. I will try remaining between 75-150 mg/day of Effexor. I began to experience what I can only guess is a form of serotonin syndrome when going up to 150 mg/day after only two days at 75 mg/day. That was silly of me. I became mentally altered. I felt dissociated and detached from my environment. Lots of bruxism. I skipped my dose of Effexor today. I take it in the morning.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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