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Re: Let's talk about combing SSRIs and TCAs

Posted by SLS on June 23, 2018, at 1:16:41

In reply to Re: Let's talk about combing SSRIs and TCAs » SLS, posted by TriedEveryMedication on June 23, 2018, at 0:33:55


> I've tried these: vortioxetine + desipramine. paroxetine + desipramine. effexor + desipramine. prozac + desipramine. I think out of that bunch, prozac + desipramine works the best. I definitely feel better, though I feel like I could feel even better and I've hit a plateau. Only real problem with this combo as I mentioned before is potential QTc prolongation. effexor + desipramine seemed to work, but my mood would crash towards the end of the day.

Effexor + desipramine:

What dosages of each?
How did you divide your dosages.

I experience a deterioration in mood at the end of the dosing period when I take Effexor XR only once a day. I take both drugs in divided doses. My mood is more consistent when I do this.

How did you react to the combination of vortioxetine + desipramine? I started vortioxetine 5 mg/day today in combination with drugs that will hopefully work synergistically to effect a robust improvement in my bipolar depression.

Currently:
Trintellix (vortioxetine) 5 mg/day
nortriptyline 100 mg/day
Lamictal 300 mg/day
lithium 300 mg/day
prazosin 30 mg/day

I recently discontined Abilify for increase body weight and high triglycerides.
I discontined Panate because the partial improvement I experienced early in treatment slowly disappeared and represented a dead end. At higher dosages, Parnate actually made me feel lazy (reduced interest and little motivation), and got nothing done.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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poster:SLS thread:1099256
URL: http://www.dr-bob.org/babble/20180521/msgs/1099268.html