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Re: Switching from Abililfy to Saphris.

Posted by SLS on June 3, 2018, at 20:55:58

In reply to Re: Switching from Abililfy to Saphris., posted by SLS on May 17, 2018, at 7:48:04

Hi, Folks.

> > I have been taking 15 mg/day of Abilify for quite a few years. I gained 50 pounds and my triglycerides are 450 mg/dL. I would like to reverse these conditions. I took my first 5 mg dose of Saphris tonight. My plan is to cross-titrate the two drugs. My hope is that Saphris will provide approximately the same antidepressant effect as Abilify, but without the weight gain and metabolic side effects.
> >
> > We shall see.

> So far, so good. I have been on Saphris 10 mg/day for a week, and discontinued Abilify 3 days ago. I feel better now than I did before making the switch. Of course it could be temporary. Abilify leaves the body somewhat slowly. Its half-life is 3 days. However, I remain optimistic. I have more energy and accomplish a bit more during the day. My thought speed and memory have improved. I am more social. My affect is less flat and my thoughts and feelings are more positive. I still suffer from laziness and a lack of interest and motivation. I also remain in a brain fog and stare off into space a lot. These things, while being symptoms of depression, are made worse by Parnate. This is my reason for wanting to switch from Parnate to Trintellix. I will do this once I have been stabilized on Saphris for a few weeks. Trintellix was my doctor's idea. I originally wanted to go back to Effexor, a drug that I have had partial success with in the past. His idea is much better. I am excited to make the switch.

So far, not so good.

Things have turned foul on me. Not only did I lose the improvement that I enjoyed during the first week or two on Saphris, but I am feeling decidedly worse. I'm pretty sure that I am in a darker place now than I was before adding Abilify to my treatment in 2002. I have decided to discontinue Saphris for now and plan to switch from Parnate to Trintellix. However, I don't plan to add back Abilify - at least, not yet. My main consideration for avoiding Abilify is that I am unhappy with the weight gain and elevated triglycerides it produces.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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