Posted by Mtom on May 21, 2018, at 12:39:45
In reply to Re: How long can feeling worse on AD's last til better » Mtom, posted by SLS on May 20, 2018, at 20:27:55
My depression seems somewhat worse too, but that might be because of the added burden of the start-up anxiety/jitteriness (and the AD not yet kicking in).
In any event, as previously noted, lots of websites mention feeling worse initially (and I have found some more since my last post), but are vague or contradictory on how long this lasts. Some say you have to give the AD time to reach steady state and kick in. Some postulate that this initial "activation" syndrome may be why many patients discontinue AD's very early.
Wish it was better characterized, but post-marketing studies are limited, small samples, often compare only 2 AD's, or 1 AD vs placebo. I read 78% of all studies are funded by the Pharma companies and several post-marketing papers by other researchers say Pharma results often do not reflect what is seen in Clinical Practice, including down-playing of side-effects.
> Thanks for the information. In retrospect, I can see how this can happen. I forgot about the startup anxiety. I guess I was focusing more on depressed mood.
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> Thanks again.
>
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> - Scott
poster:Mtom
thread:1098789
URL: http://www.dr-bob.org/babble/20180521/msgs/1098812.html