Posted by ed_uk2010 on March 24, 2018, at 16:13:39
In reply to Re: How can I block Cortisol? » ed_uk2010, posted by farshad on March 24, 2018, at 14:09:38
Hi F,
>that inhibits 11b hydroxylase. wouldnt that lead to less CRH release?
Not as far as I know. It leads to lower cortisol and higher ACTH like other cortisol synthesis inhibitors.
>btw what happens if u have high 11-Deoxycortisol lvls? Since inhibiting 11b hydroxylase will increase 11-Deoxycortisol, im wondering what the conseuqneses of that is .. increased aldosterone??
Metyrapone does increase 11-deoxycortisol, yes. The effects of this during Cushing's treatment aren't entirely clear.
In terms of aldosterone, metyrapone itself reduces aldosterone synthesis.... but because it increases ACTH, it may lead to the body attempting to produce more aldosterone. The overall effect could be either more OR less aldosterone being produced. During treatment, doctors carefully monitor potassium levels to help keep track of this.
>no havent been to the doc yet. becus i dont know what to test for.
I asked you but you didnt answer. am I supposed to test for Cortisol and ACTH ?I did answer :) Testing ACTH is not usual when initially looking for the possibility of high cortisol, no.
Although it's up to your doctor, and depends on your local lab, common tests when looking at the possibility of high cortisol are the overnight dexamethasone suppression test, and the 24 hour urinary cortisol collection test.
>is it possible to test for CRF1?
No, it's not possible to test for the level of CRF-1 receptors.
Alcohol is a common substance believed to activate CRF-1. So if you don't already, you could try a period of no alcohol and see if it helps your mental health.
poster:ed_uk2010
thread:1097352
URL: http://www.dr-bob.org/babble/20180212/msgs/1097653.html