Posted by farshad on March 19, 2018, at 14:20:38
In reply to Re: How can I block Cortisol?, posted by farshad on March 19, 2018, at 14:16:15
> > has anyone seen this study ? its from 1998 . I think they are suggesting there could be CRF1 mutations but unrelated to cushings disease>
> >
> > I quote from the study ...No mutations affecting the CRF1-R protein have been found in all tumors analyzed. However, we found a significant overexpression of the CRF1-R messenger RNA in ACTH-secreting pituitary adenomas vs. inactive adenomas and normal pituitaries. We conclude that mutations of the CRF1-R are unlikely to be involved in Cushing's disease. We suggest that the overexpression of the CRF1-R messenger RNA may be related to a disturbed receptor regulation in ACTH-secreting pituitary adenomas...
> >
> > https://www.ncbi.nlm.nih.gov/pubmed/9745449
> >
> > English is my 3rd language so maybe someone can explain this that understands it better_
>
> I found 2 possible mutations that I have related to ACTH>
>
> PDE8B https://www.selfdecode.com/gene/pde8b/#advanced-summary
>
> ACE (Angiotensin I converting enzyme) https://www.selfdecode.com/gene/ace/--------------
One mutation in human PDE8B (His350Pro), from a patient with severe adrenal hyperplasia, impaired PDE8B catalytic activity, and its expression in Hela cells resulted in increased cAMP-signaling, suggesting a role for cAMP in development of adrenal hyprerplasia. Such PDE8B mutations may not directly cause adrenal hyperplasia, however, since PDE8B KO mice do not develop adrenal tumors (Tsai and Beavo 2011). Inactivating PDE11A gene mutations are also associated with the development of adrenal hyperplasia and Cushing syndrome (Libe et al. 2008), and with Carney complex (CNC). CNC is caused by germline mutations in the alpha regulatory subunit of PKA (PRKARIA) and is associated with endocrine tumors, including nodular adrenal hyperplasia and adrenal and testicular tumors (Levy et al. 2011;Libe et al. 2011). PDE11A mutations may also play a role in susceptibility to prostate cancer (Faucz et al. 2011) and testicular germ cell tumors (TGCT) (Horvath et al. 2009).
------------https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275405/
https://en.wikipedia.org/wiki/Congenital_adrenal_hyperplasia
poster:farshad
thread:1097352
URL: http://www.dr-bob.org/babble/20180212/msgs/1097509.html