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Re: **TRIGGER** Current meds and question » ed_uk2010

Posted by SLS on March 16, 2018, at 15:23:14

In reply to Re: **TRIGGER** Current meds and question » Clearskies, posted by ed_uk2010 on March 16, 2018, at 8:20:11

Hi, Ed.

Paxil and Wellbutrin are both CYP450 2D6 inhibitors as I remember. What kinetic interactions would one expect when combining these two drugs? Would you need to reduce the dosage of both, or just one?

In my estimation, combining the following drugs would address both anxiety and depression (unless Wellbutrin has already demonstrated anxiogenesis).

1. Effexor
2. Wellbutrin
3. Nortriptyline

People don't seem to like suggesting Effexor these days. Is it the withdrawal that is the problem? I have seen it work magic.

How long must someone take Effexor before withdrawal becomes an issue? I have taken Effexor for months without suffering too badly when I discontinued it using a rapid, but flexible taper. I may be unusual in this regard. I have speculated in the past that some anticonvulsants might reduce the magnitude of SSRI / SNRI / BZD withdrawal effects. I am most interested in oxcarbazepine for this.

How would you compare citalopram with escitalopram when it comes to treating comorbid MDD and GAD?

How would you rate the withdrawal syndromes produced by discontinuing sertraline and citalopram?


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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