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Re: How can I block Cortisol?

Posted by ed_uk2010 on March 16, 2018, at 10:52:50

In reply to Re: How can I block Cortisol? ed_uk2010, posted by farshad on March 16, 2018, at 8:53:47

Hi,

Unless you have elevated cortisol levels as demonstrated by an endocrine specialist, you would not want to take any anti-cortisol medication. You could end up absolutely exhausted and very sick, and may potentially collapse. Cortisol is a hormone which is necessary for life. Without it, we would be dead.

Although some people with mental health problems have disruption of the HPA axis, you would not use these drugs in psychiatry unless it was part of a clinical trial with specialist blood monitoring. The HPA axis should normalise when the mental health condition is treated with a psych medication, or psychological therapy.


About the meds you asked about:

>Spironolactone - this drug has a wide array of hormonal effects, such as blocking testosterone and aldosterone. It is not used in any mental health condition. It is useful in chronic heart failure, ascites of liver disease and occasionally in combination with estrogens as part of a male to female sex change.

>Mifepristone - This abortion drug is supplied to specialist clinics only. Any other use would need to be part of a clinical trial.

>Metyrapone - it would be very dangerous to take this drug without specialist monitoring. It could lead to a dangerous drop in cortisol levels.

>Ketoconazole and miconazole - when taken by mouth, these drugs can cause liver damage. Ketoconazole tablets have been discontinued in most countries.

 

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