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Re: Is Modafinil a Weak Dopamine reuptake inhibitor? farshad

Posted by ed_uk2010 on March 3, 2018, at 16:01:03

In reply to Is Modafinil a Weak Dopamine reuptake inhibitor?, posted by farshad on March 3, 2018, at 4:35:16

>according to the Modafinil own page it says at 300mg Modafinil inhibits 50% dopamine transporters, thats not weak.

It could be weak according to the clinical effects exerted; even though 50% 'sounds' like a decent percentage, it may not be.

If you look at SSRIs for example, a dose which blocks 50% of transporters is not clinically effective. The dosages used in practice block a much higher percentage of transporters.

The same sort of situation applies to antipsychotics when used in psychosis. Blocking 50% of dopamine D2 sites does not appear useful. Therapeutic doses of most antipsychotics block a much higher percentage.




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