Posted by ed_uk2010 on March 1, 2018, at 21:51:44
In reply to Re: Switch from amitrip to noritrip due to poop out? » ed_uk2010, posted by SLS on March 1, 2018, at 20:53:25
> Would Cymbalta (duloxetine) be of any value?
I think that's a really interesting idea, but it does bring up some potential issues:
1. I don't think duloxetine has been studied much in chronic bladder pain. I did find an abstract from an observational study, but it didn't appear to be effective or well tolerated.
2. Duloxetine can be useful for stress incontinence, but AFAIK, urgency and frequency are much more common in interstitial cystitis.
Anticholinergics, rather than duloxetine, are often useful for urgency/frequency - which could be part of the reason why amitriptyline sometimes reduces these symptoms.
3. I'd wonder whether a therapeutic dose of duloxetine would be an issue while taking paroxetine. Mainly in terms of serotonergic adverse effects.
Just some thoughts really.
poster:ed_uk2010
thread:1097097
URL: http://www.dr-bob.org/babble/20180212/msgs/1097112.html