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Re: Quitting Effexor After 20 yrs Mission7

Posted by SLS on January 30, 2018, at 15:59:11

In reply to Re: Quitting Effexor After 20 yrs, posted by Mission7 on January 30, 2018, at 11:03:48

> I remember when I first took Effexor it gave me a sense of euphoria. IT WAS FUN! Over the years, it changed to something that just prevented major episodes and anxiety attacks.
> I would like to try an older $SSRI with characteristics not unlike Effexor at low doses. The highest does I maintained was 150mg/day

Why do you want to limit yourself to an older SSRI? They are more likely than Effexor to produce apathy and sexual side effects.

No SSRI can act like low dosages of Effexor. The first SSRI that doctors choose now is Lexapro.

Only 150 mg/day of Effexor?

If you decide to return to Effexor as a treatment, I would investigate going up to at least 300 mg/day if you can tolerate it. 450 mg/day is not unheard of. I think there is something that higher dosages of Effexor have that Pristiq, the metabolite of Effexor, lacks. I don't know of anyone who failed to respond to high dosages of Effexor who went on to respond to Pristiq at 100 mg/day. Maybe someone else can comment.

Another avenue might be to work with drugs that inhibit the reuptake of serotonin and modulate receptors at the same time. Viibryd and Trintellix are examples. I may try Trintellix (vortioxetine). It is supposed to be pretty clean and works to improve cognition, even in the absence of an antidepressant effect. If I fail to respond to it, I am going to try Effexor 300-450 mg/day.

I am most interested to see what others have to say here.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw




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