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Re: Could Provigil / Nuvigil be antimanic?

Posted by PeterMartin on January 29, 2018, at 13:12:46

In reply to Re: Could Provigil / Nuvigil be antimanic?, posted by SLS on January 29, 2018, at 9:18:47

> > Btw: On the other hand typical stimulants like Ritalin and Adderall have been in my system a few times when I've gone manic. I feel they're risky and if anything push me towards mania.
>
> You might find this helpful:
>
> Use of adjunctive stimulants in adult bipolar depression
>
> https://academic.oup.com/ijnp/article/16/1/55/629710
>
>
> - Scott

Thank you!

--
Armodafinil 150 mg/d (n = 128) and placebo (n = 129) were administered once daily in the morning. The primary outcome measure was change from baseline in the total 30-item IDS score. Secondary outcomes included changes from baseline in scores on the MontgomeryÅsberg Depression Rating Scale (MADRS; Montgomery & Åsberg, 1979), as well as IDS and MADRS response rates. At endpoint, adjunctive armodafinil compared to adjunctive placebo yielded significantly greater improvement in mean IDS scores, but failed to separate on any of the secondary outcomes. Most frequently reported adverse events in patients receiving adjunctive armodafinil were headache, diarrhoea, and insomnia. Of note, armodafinil was not associated with an increased incidence and/or severity of suicidality, depression, or mania or with changes in metabolic profile measurements.
===


I wish it made me feel a little better (or less slow) but at least there's some proof it shouldn't cause mania on its own.

I wish I could switch to something like Vyvanse or Concerta as I think these would do more to help me be productive (and stay awake). That said I think there is potential for someone to go manic on those (especially when combined w/ an MAOI and limited anti-manic stabilizers).

Currently:
Nardil 60 (recent chance from Marplan)g
Armodafinil 150 to 200 (Morning/Evening)
Lamictal 150
Metformin 1000 (starting)
Seroquel 25mg (Sleep but will prob increase to 50/100)


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poster:PeterMartin thread:1096752
URL: http://www.dr-bob.org/babble/20161215/msgs/1096755.html