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Re: Grandma developed severe dementia Lamdage22

Posted by SLS on November 28, 2017, at 19:17:29

In reply to Grandma developed severe dementia, posted by Lamdage22 on November 22, 2017, at 12:41:50

I'm sorry about your grandmother.

Statistically, people with Alzheimer's Dementia who are treated with neuroleptic antipsychotics die sooner. I don't think scientists know why yet.

A serotonin 5-HT2a receptor antagonist (or better yet, an inverse agonist) is thought to reduce pscychosis in Alzheimer's. I'm thinking maybe cyproheptadine (Periactin) would be helpful. It is not a neuroleptic antipsychotic. It tends to be sedating due to its antihistaminergic properties. This might be a desirable side effect. I believe that risperidone (Risperdal) is unique among APs in that it is an inverse agonist at 5-HT2a. Perhaps a low dosage can be sufficient to deal with agitation.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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