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Re: Nardil immediate relief and early poop out

Posted by linkadge on September 10, 2017, at 20:13:24

In reply to Re: Nardil immediate relief and early poop out linkadge, posted by SLS on September 10, 2017, at 19:19:42


Strangely enough, I have never tried Wellbutrin. I was on a combination of Effexor and methylphenidate, which worked fairly well, but the methylphenidate was a bit harsh.

For herbs, turmeric, rhodiola, cocoa and quercetin are fairly potent MAOIs. I did use fo-ti (contains emodin - a relatively selective MAO-B inhibitor), but backed off of it due to reports of possible liver issues. I remember reading an article suggesting that rhodioloa could inhibit ~50% of MAOA with a standard dose.

Cocoa powder is one of my mainstays. I find it has an effect on depression, cognition, anxiety and stability. Epicatechin (in cocoa) is a MAOI (more selective towards MAOB) and also has some monoamine reuptake effects (selective towards norepinephrine reuptake). Harmaline (in coffee and cocoa) is selective towards MAO-A and has some serotonin reuptake inhibition as well. Interestingly harmaline is a gaba-a antagonist as well. Some research suggests that gaba-a antagonists can have antidepressant effects (but perhaps increasing anxiety).

I found the combination of turmeric and quercetin fairly potent. Interestingly, I had serotonin syndrome when combining citalopram with a few grams of turmeric. Tumeric is probably one of the most potent herbal antidepressants IMHO.

Quercetin, however, is also a COMT inhibitor. Rambling here but, COMT inhibitors also have antidepressant properties which (surprisingly) have never much been explored pharmacologically.





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