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Re: Med washout to focus on sleep SLS

Posted by linkadge on August 15, 2017, at 14:57:41

In reply to Re: Med washout to focus on sleep, posted by SLS on August 14, 2017, at 21:20:15

Hi Scott,

You may be right. However, the only additional effect which would become pronounced at higher doses would be the alpha-2 effect. I think the 5-ht2 receptors would become saturated at much lower doses.

From reading patient experiences, mirtazapine seems to loose its effect as an antidepressant sooner than other drugs, although it may work faster.

Amitriptyline has more targets (i.e. reuptake inhibition, trk agonism, anti-muscarinic effects, ion channel effects).

On a scale for likelihood to induce mania, I would put mirtazapine on the lower end, and the TCA's on the higher end.

But that's just my 2 cents.

Linkadge




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poster:linkadge thread:1094409
URL: http://www.dr-bob.org/babble/20161215/msgs/1094437.html