Posted by Jonhed on October 31, 2016, at 10:55:05
In reply to Re: NSI-189, posted by SLS on October 23, 2016, at 12:49:46
The thing about ampa receptors is interesting!
I have abused ketamine for a while and I find that when on memantine, I can't seem to get "high" of ketamine, and I think that it has to do with the ampa receptors being blocked in some way or just that memantine is voltage gate dependant and doesn't "allow" ketamine to shut down my glutamate receptors..
Just an interesting thing.
I also know that when iv'ing ketamine you activate the u-opioid receptor to a much greater extent than when you use it intranasal. Mostly because you need very high doses to make it function as an full agonist at that site.
And yeah, you are definitely right about the ampa receptors being the necessary site to block, cause the glutamate site just gives you the dissociative effect.
poster:Jonhed
thread:1092714
URL: http://www.dr-bob.org/babble/20160928/msgs/1092873.html