Posted by sacct on August 5, 2016, at 20:24:40
In reply to Re: no meds working? » sacct, posted by SLS on August 5, 2016, at 18:25:35
> Hi.
>
> > huh. I was on lamotrigine and it did nothing. this is some funky news.
>
> It turns out that one must finesse the dosage of anticonvulsants (AED) to a much finer degree than most other classes of drugs. This may be because the therapeutic window for these drugs is relatively narrow when treating seizure disorders. Although this is true when treating epilepsy, I don't know to what degree this is true when treating mood disorders.
>
> The FDA says that it is a myth and not true that it allows a 20% - %25 difference in bioavailability in blood levels between name brand and generics. It is more like 3.5% according to what I read. Differences are supposed to be within 1 standard deviation. It is obvious to me that this is enough of a deviation for me to respond differently to various preparations of lamotrigine; Mylan generic being substantially inferior to name brand and Teva brand. That Mylan has been approved for sale by the FDA makes me question the quality of the evaluation of this particular preparation by the FDA rather than the FDA standards themselves.
>
> > could it be that most of the meds had little effect because they were half-*rs*d generics?
>
> I wouldn't worry about this too much.
>
> I think more generics are acceptable than not. Out of the six psychiatric drugs that I take, 5 are generic and work very well. The one exception is lamotrigine.>
> - ScottYou're probably right. I just think I am fustrated with the meds not working at all. it seems farfethed for the meds to not work at all rather than them working somewhat. or just having side effects.
poster:sacct
thread:1091064
URL: http://www.dr-bob.org/babble/20160713/msgs/1091180.html