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Re: Fluvoxamine

Posted by jonhed on May 28, 2016, at 9:16:28

In reply to Re: Fluvoxamine, posted by jonhed on May 28, 2016, at 8:44:15

My last Pdoc prescribed us patients, with either diazepam or methadone as medicine, one white grape fruit a day instead of upping the dose when he thought that we had "hit the roof".

He did an dissertation in the subject, Cytochrome P450 enzyme inhibitor and medicines. Something like that.

And when the methadone was at 100 mg daily, respectively 40 mg diazepam daily, he would give us one ecological white grapefruit a day that was to be eaten one hour before medication.

He said that in diazepam, 40 mg is equal to about 47 mg with grape one hour before, but without all the possible side effects with 7 mg more. That is because of diazepam undergoes a great variation of metabolism in your body and when CYP3A4 is inhibited to an extent the active metabolites, such as desmethyldiazepam and oxazepam will be more present but in another way.
I don't remember all off it, don't blame me for that if you know how your memory gets when you eat valium! hehe.

And methadone 100 mg + grape = 110mg, same thing there but different metabolism.

But be aware, his dissertation was not about antipsychotics or any other drug.
But i think it is worth mentioning anyway, because if you can raise the serum level without raising your medicines, you will in many cases get rid of the harmful inactive metabolites :-)


In some cases when the substance HAVE to undergo metabolism to become active, this will be very very counterproductive..


I want to mention that last night i got psychosis because i tried to do a cold turkey with zopiclone and nitrazepam (been on it for 4 years), and this was day 10 without zopiclone and day two without any benzodiazepine whatsoever.

Damn, now i get it. This is heavy medicines we are dealing with.
I took 15mg zopiclone and the hallucinations faded in 15 minutes.

7th juni i will get detox with diazepam for 4-6 weeks, then i will never take another benzo..

But it is important to follow your doctors advice, now i know that!

Hope you're doing better today lamdage22.


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poster:jonhed thread:1089211
URL: http://www.dr-bob.org/babble/20160501/msgs/1089284.html