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low dose abilify as a add-on to move my butt -Oops » Noa

Posted by SLS on December 25, 2015, at 21:15:06

In reply to Re: low dose abilify as a add-on to move my butt » SLS, posted by Noa on December 25, 2015, at 19:08:42

Sorry, Noa.

Even with your list right in front of me, I thought for some reason that you were currently taking Brintellix.

<sigh>

Anyway, Brintellix seems like a good drug to keep in mind. It is seen as being more of a serotonin system modulator than a simple reuptake inhibitor. It is a cognitive enhancer. It has a much reduced potential for producing sexual side effects, and weight gain tends not to be a problem. As is with many other antidepressants, it increases norepinephrine and dopamine in various brain regions.

It is encouraging that you are beginning to tolerate the Abilify. A generic version has been approved, but I don't know when it will become available. Perhaps your insurance would cover that.

Brintellix (vortioxetine) and Abilify have a few important properties in common:

5-HT1a agonism (Abilify = partial agonism)
5-HT2a antagonism
5-HT7 antagonism

You might be sensitive to drugs that are norepinephrine reuptake inhibitors (NRI). That could explain your reactions to Seroquel and TCA. The major metabolite of Seroquel is a NRI. If this is true, Wellbutrin may have produced anger or anxiety, and Ritalin would not have treated you very well. This is just a guess. Also, higher dosages of Effexor also become NRI.

FYI, thyroid hormones increase the sensitivity of norepinephrine receptors. For me, Cytomel (T3) made me insanely worse while Synthroid (T4) made me feel somewhat better. I never researched this.

I hope you feel better soon. Sorry I couldn't be of more help.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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