Posted by SLS on December 2, 2015, at 7:17:35
In reply to Re: Where can i follow Glyx-13 (Rapastinel) progress?, posted by Lamdage22 on December 1, 2015, at 14:25:38
Hi Lamdage.
I apologize for changing the topic somewhat.
I hope these ketamine-like drugs become available quickly for you to try. If it is effective for depression, I would like to see NRX-1074 become available. It is administered orally, and is supposed to be without psychotic or dissociative side effects. Also, keep an eye out for a metabolite of ketamine, hydroxynorketamine (HNK). This orally-administered drug appears to be effective, and avoids blocking the NMDA receptor. It is without psychotic side effects. The commonality to all of these drugs is that they produce an immediate increase in BDNF production and the sprouting of neurites.
How is the buspirone working out for you?
By the way, have you ever tried Abilify? I imagine you have. How did you react to it? Do you recall the dosage?
Do you continue to have moderate-to-severe psychotic symptoms?
One more question. In what ways does the high dosage of Seroquel help you?
One more one more question (sorry). Can you better detail exactly what depressive symptoms you are currently having difficulties treating? It might allow people to be of more help to you. For example:
- Loss of interest in hobbies or pleasurable activities
- Lack of motivation to initiate activities and get things done
- Slowed movement or difficulties in initiating movement (psychomotor retardation)
- Lack of mental and physical energy (anergia)
- Lack of feeling pleasure or reward in doing things (anhedonia)
- Reduced sex-drive
- Slowed thoughts or cognitive impairments
- Memory impairments - particularly short-term memory
- Difficulty reading or concentrating
- Sadness
- Insomnia - especially early-morning
- Hypersomnia
- Lack of appetite
- Depressed mood or dysphoria
- A tendency to stare into space in the absence of thought.
- Thoughts of suicidal or self-harm
- Agitation, anger, or irritability
- Air hunger or sighing
- Tearfulness
- Melancholic thoughts
- Difficulty in making decisions
- Feelings of hopelessness or helplessnessI have most, but not all of these. Importantly, depressed mood, melancholy, and sadness are no longer problems for me. They were early on. Anxiety is no longer a problem for me, either. The features of depression can change over time.
One more thing. I was thinking about you early this morning and your frustrations with treatment. Unfortunately, I think you will need to give medication more time to work than the average person. You may need to give most drugs a full 12 weeks to work. I have seen this occur quite a few times with people with TRD here on Psycho-Babble. My guess is that this is a function of the length of time one has been ill plus the number of drugs the brain has been exposed to. Of course, ketamine and its analogues are exceptions. At the right dosage, these drugs can make one feel better within 4 - 24 hours.
The drugs I am taking help me, but are far from producing a robust improvement or remission. I am therefore using them as a bridge to the emergence of very different treatments. It's the best I can do right now. I'll take whatever I can get.
Currently:
Parnate 80 mg/day
desipramine 300 mg/day
Lamictal 300 mg/day
lithium 300 mg/day
Abilify 10 mg/day
prazosin 30 mg/dayI just switched from nortriptyline to desipramine. It helps more with mental energy and concentration. My goal is to return to work and meet new people. I can see myself doing this if I experience a moderate improvement. With a little luck, I will feel well enough to do these things after giving this treatment a few months to work without making any changes.
- Scott
Some see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1084317
URL: http://www.dr-bob.org/babble/20151119/msgs/1084330.html