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Re: Asenapine (Saphris) for OCD » phidippus

Posted by SLS on September 10, 2015, at 7:47:33

In reply to Re: Asenapine (Saphris) for OCD » MuseMemento, posted by phidippus on August 30, 2015, at 19:12:42

> Sertraline and Fluvoxamine have one thing in common: they both agonize sigma-1 receptors. So, if you respond to Zoloft, you may respond to Luvox.

Don't these two drugs act in an opposite manner with respect to sigma-1 receptors? I believe sertraline is an antagonist.

I found this article interesting regarding psychotic depression:

http://www.ncbi.nlm.nih.gov/pubmed/20492642

There is also some evidence that fluvoxamine (Luvox) can actually reduce the severity of akathisia produced by aripiprazole (Abilify).


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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