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Dosing Qs - aptiom/pregabalin

Posted by GingerbeerBloke on June 20, 2015, at 5:25:13

I've noticed that Aptiom seems to wear out a bit some hours before and after my scheduled dose. I'm on 1200mg and taking it for rage issues. I get some amount of outbursts during these wear-out times but otherwise I'm stabilized. I'm on a once-daily dose. It's been a month since I'm on Aptiom. Would a divided dose have a more stable effect on me? Please give me insight on why and why this happens even though it has a long half-life and if I need to divide the dose, what amounts should I divide it as.

I'm also going on pregabalin (but I'm adding Stablon first for my severe depression issues after having indifferent response on some SSRIs and one SNRI). I'm interested to know what is the best way to dose and titrate pregabalin and what issues I might come across (I'm aware of bioavailability issues with gabapentin). I'll be taking pregabalin for a few issues. One is to eliminate anxiety and reduce stress-levels greatly, that is in the hopes that I can function better and prevent irritability that may be fueled a bit by excess stress. I'm also hoping it might prevent rage attacks which I've hypothesized might be coming from pent-up sub-clinical seizure activity (after reading a bit about episodic dyscontrol syndrome). I've had very good response to aptiom (albeit a slightly incomplete response) which is remarkable considering I've dropped all antipsychotics and still functioning well after a month - all doctors said nothing but strong APs like risperdal and clozapine would work, I took the chance and aptiom monotherapy is working for me but I'm so unhappy about the persistent EPS and severe dystonia that I suspect might have become permanent from the APs. I'll also be taking pregabalin in the hopes that it will improve the quality of my sleep and give me deep sleep. Some people have had good AD response from it as well. So for my issues, please advise on what might be or your opinion on proper dosing.


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poster:GingerbeerBloke thread:1079862
URL: http://www.dr-bob.org/babble/20150520/msgs/1079862.html