Posted by tiopenster on May 30, 2015, at 21:58:09
I seem to really react poorly to SSRIs, SNRIs, Serzone, Buspar because they mess with the 5ht1 receptor. I get a lot of anti-anxiety benefit from Remeron (probably because it doesn't touch that one, but it turns me into a zombie. I am having decent success so far with the German medication Insidon, but don't know where I can find it online anymore. (help with that would be greatly appreciated) (It doesn't touch 5HT1) I'm looking for other alternatives if I can't refill what I have.
What I experience on these meds with 5ht1 is immediate positive feelings within a day and then day 3 or 4 I crash terribly and go ballistic with intense anxiety. Then I'll go manic or depressed or normal - I rapid cycle even though I'm not bi-polar.
Neurontin doesn't help me with my anxiety although Lyrica is excellent for about 1-2 weeks and then poops out.
To get my last bought of anxiety under control I was on Geodon, Lyrica, Lamictal, Remeron & Klonopin. I was a zombie though! I was fine for 2 years and then relapsed as I was slowly tapering off klonopin.
I don't know how I would respond to Brintallix because it does affect 5ht1, but it has a novel approach. It's not a reuptake inhibitor, but a a serotonin modulator and stimulator. I really don't now if I have a problem with the reuptake process or 5ht1 regardless of all mechanisms.
Thanks in advance
poster:tiopenster
thread:1079343
URL: http://www.dr-bob.org/babble/20150520/msgs/1079343.html