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Re: Neurobiology of OCD - speculation

Posted by Bill82 on February 24, 2015, at 13:37:53

In reply to Re: Neurobiology of OCD - speculation, posted by SLS on February 21, 2015, at 7:37:53

Got my genetic testing back some interesting stuff. Was prescribed lamotragine so we will see how that goes. Worried about memory or libido problems but have told myself I will just white knuckle it until he says to stop, unless of course I have serious side effects such as steven johnson rash or other allergic reactions. Anyways check out the results and if you have any hhoughts post them I'd love to hear.

SLC6A4- result-L(A)/L(G)

Serotonin Transporter-patient exhibits a mutation of the serotonin transporter associated with reduced reuptake of seritonin, less satisfactory response to ssri, and a potentially greater risk for adverse effects from ssri. This variant has also been associated in literature with lower stress resilience and higher rates of PTSD.

5ht2c -Serotonin Receptor result- C/C

Serotonin has potent satiety signaling activity and 5ht2c antagonism has been shown to lead to increased food intake. This patient exhibits a variant of the 5ht2c receptor which has been associated with satiety in the hypothalamus.

CACNA1C Calcium Channel-result G/A

The patient exhibits a variant in the gene coding for a subunit L-type voltage gated calcium channel. Days regulation of this channel has been associated with changes in neuronal depolarization, amygdala volume in schizophrenics and bipolar patients, frontal hippocampus connectivity, disruptions in cognition in both schizophrenic and bipolar patients, and has been hypothesized to be related to glutamate signaling. Clinically has been associated with conditions charecteriEd by mood instability or lability.

Mtfhr-impared folic acid metabolism and blunted activation in the anterior cingulate.

CYP2D6 - cytochrome P450 2D6- result - intermediate metabolizer

Reduced hepatic degradation and higher plasma levels of flouxetine fluvoxamine paroxatine sertraline duloxetine venlafaxine mirtazipine nefazadone apriprazole haloperidol iloperidone risperidone atomoxetine amphetamine-dextrothetamine methamphetamine olanzapine codeine methadone tramadol vortioxetine TCA's phenothiazines

CPY2C19 Cytochrome p450 2C19- result - ultra rapid metabolizer

Poorer efficiency and reduced plasma levels of citalopram escitalopram diazepam clomipramine imipramine trimipramine




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