Posted by ed_uk2010 on February 14, 2015, at 9:35:12
In reply to Re: Effexor + Mirtazapine MORE effective than PARNATE!, posted by burial on February 14, 2015, at 8:54:45
>According to this study, venlafaxine occupies 60% of NET and it may be that the metabolite, desvenlafaxine gives even more NET.
With venlafaxine, occupancy of NET appears to be a function of the dose. Occupancy is significant at high doses. Occupancy of SERI is high across the entire dose range, and very high at high doses.
>it may be that the metabolite, desvenlafaxine gives even more NET.
The 60% figure should refer to the total occupancy/inhibtion, I would imagine, not occupancy only by venlafaxine itself. Unfortunately, a blood test was used in this study as an estimate of NET occupancy. PET scans provide a better estimate.
>I once read a study that desipramine occupied 80% of NET so it isn't that huge of a difference
I think that's about right. The difference could well be significant though. For SSRIs, as an example, 60% SERT occupancy may be right at the bottom end of clinically effective inhibition. In fact, some studies have suggested that effective SSRI doses usually produce around 80% occupany, with 85-90%+ at high doses. Whether similar percentages apply to NET occupancy is unclear.
poster:ed_uk2010
thread:1040126
URL: http://www.dr-bob.org/babble/20150129/msgs/1076600.html