Posted by ed_uk2010 on January 30, 2015, at 10:16:21
In reply to so...wellbutrin sr..., posted by Christ_empowered on January 30, 2015, at 9:14:36
Hi CE,
>I just need something to help concentration, mostly, but a little bit of a mood lift would be nice, too.
What sort of concentration problems do you have? I was wondering whether taking Trileptal in combination with Lamictal impairs concentration at all?
>OK. And...when combined w/ a neuroleptic...is Wellbutrin still effective?
To be honest, it's not really know how Wellbutrin works! It's a unique drug which remains rather mysterious. Despite being chemically similar to certain stimulants, it's far less dopaminergic than the abused psychostimulants. Wellbutrin itself is a very weak dopamine reuptake inhibitor, a weak NE reuptake inhibitor and an antagonist of certain nicotinic receptors. One of its metabolites is an NE reuptake inhibitor too - which could account for its antidepressant effects as well as its apparent efficacy in ADHD.
I don't think Abilify will prevent Wellbutrin from helping. After all, there's very little evidence that Wellbutrin works via dopamine pathways at all. The very weak dopamine reuptake inhibition may not be enough to produce any elevation of dopamine levels. Wellbutrin mainly works though other mechanisms, it seems.
Occasionally, people report feeling that their concentration is impaired by Wellbutrin, rather than the improvement which might be expected. You can only try it and see....
If you suffer from insomnia, it might be worth taking 100mg in the morning for a few days to test for tolerability before increasing to 100mg twice a day.
poster:ed_uk2010
thread:1075779
URL: http://www.dr-bob.org/babble/20150129/msgs/1075781.html