Posted by LouisianaSportsman on October 11, 2014, at 22:44:18
In reply to Re: viibryd -- and SLS, are you out there? :), posted by oceansun on October 11, 2014, at 22:30:05
Pregabalin (Lyrica) may be the best mood brightener you could take right now, consider its cousin, gabapentin (Neurontin) as well-- at effective dosages. This will be a good anxiolytic to get you through the aripiprazole WD and stabilizes mood as well, in my case.
Riluzole may be good to augment to your Lamictal.
It possesses both glutamatergic modulating, antiepileptic, and neuroprotective properties, all of which make it a promising candidate for the treatment of mood and anxiety disorders. Clinical use and clinical investigations support riluzoles antidepressant and anxiety properties. These reports comprise either case series or open-label studies in patients with treatment-resistant conditions, especially bipolar depression and generalized anxiety disorders. The anti-anxiety effects of riluzole have been postulated to be the result of postsynaptic GABA-A receptor function potentiation in hippocampal neurons.
Matthew and colleagues (2008) found, in an eight-week open-label study, that riluzole 100 mg/day was effective in treating anxiety symptoms in patients with GAD. In this study, 80% of completers responded to riluzole, and 53% met remission criteria at eight weeks. One unique aspect of riluzole is that it does not require dose titration and the suggested initial dosage of 100mg. is indicated as effective in all-day anxiety treatment
it is very similar to Lamictal. Its neuroprotective, due to glutamate/NMDA-receptor antagonism, and it also increases the action of GABA through several mechanisms, making it perhaps an ideal candidate for some people with anxiety disorders. It has also treated depression.
Studies:
Riluzole in the treatment of mood and anxiety disorders.
CONCLUSIONS: Riluzole may hold promise for the treatment of several psychiatric conditions, possibly through its ability to modulate pathologically dysregulated glutamate levels, and merits further investigation.
Preliminary evidence of riluzole efficacy in antidepressant-treated patients with residual depressive symptoms.
CONCLUSIONS: These data suggest that riluzole augmentation produces antidepressant and anxiolytic effects in patients with treatment-resistant depression.
An open-label trial of riluzole in patients with treatment-resistant major depression.
CONCLUSIONS: Although preliminary, these results indicate that riluzole may have antidepressant properties in some patients.
poster:LouisianaSportsman
thread:1072031
URL: http://www.dr-bob.org/babble/20140914/msgs/1072128.html