Posted by linkadge on May 31, 2014, at 17:53:42
In reply to Re: Chronic Insomnia-Anyone else?, posted by linkadge on May 31, 2014, at 15:40:37
Just to add, I would say I am cured from about 5 years of the most disrupted sleep cycles.
The cure started with remeron, but I have been able to piggy back off its effect with some other supplements. This has lowered the needed dose.
Remeron was better than trazodone for sleep (for me). Trazodone isn't as potent and antihistamine, but it does have the 5-ht2a antagonist effects.
I have been able to identify about 7 sleep inducing mechanisms which can be targeted for insomnia.
Histamine (H1 antagonist)
Serotonin (5-ht2a antagonist)
Intracellular (i.e. calcium antagonists)
Gabaergic - I.e. benzodiazepine
M1 / M2 agonist - i.e. melatonin (or rozerem)
Cannabinoid (i.e. oleamide)
Opioid
PKC - i.e. mood stabilizers
GSK3 - i.e. mood stabilizers (or niacin)
remeron + magnesium + melatonin + lorazepam will affect 6 of these targets. Taking some omega-3 during the day can help bring down sensory hyper arousal (if this is a concern).If you don't have access to lorazpam, you might try taurine instead (taurine has a calcium antagonist, and gaba effect).
Linkadge
poster:linkadge
thread:1066284
URL: http://www.dr-bob.org/babble/20140512/msgs/1066304.html