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Can someone explain Namenda's MOA?

Posted by zonked on April 30, 2014, at 13:29:24

In plain English, what does Namenda (memantine) *do* to help people with brain damage (alzheimer's, and in my Mom's case, brain tumor damage) to help memory and cognition?

I am familiar with the NMDA receptor. My understanding is that it prevents excess firing somehow and thus cell death.

Someone here will know.

Also when Mom started on Namenda her neurologist suggested that at some point he may add Aricept to help. I am wondering if that's worthwhile, given her prognosis and that she appears to be doing better on Namenda.

-z


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URL: http://www.dr-bob.org/babble/20140419/msgs/1064975.html