Posted by klein on April 25, 2014, at 0:51:42
In reply to geodon, posted by Christ_empowered on April 24, 2014, at 19:31:35
> Geodon...tell me more...can you ramp up the dose if needed? Is it OK in terms of EPS?
Hey, sorry to barge in ;)
I think that the term "atypical anti-psychotic" is too broad, some of them are also jazzy antidepressants and could potentially be classified as such.
I think that Remeron and mianserin are the most effective antidepressants available. Saphris and Geodon are very similar to the tetracyclic's profile:
The difference between Abilify and Saphris / Geodon / clozapine is that Abilify is a partial agonist at 5-HT2C, and the others are very strong 5HT2C inverse antagonists; this usually gives them powerful Remeron-like antidepressant action.
Same goes for the mysterious 5-HT7 receptor, Abilify is a partial agonist and the others are strong antagonists.
Abilify is really complicated, the dose needs to be adjusted continuously. It can work great for a while and then turn on you. It's neither here nor there. The manufacturer wanted to label it a "neuromodulator" (promptly shot down). The whole partial agonism business is strange, sometimes lowering the dose down to 5mg - or even 1mg - can reverse its action.
Saphris and Geodon are more straightforward.
I find that Saphris works almost immediately.
Geodon is usually activating in low doses (20mg BID) and more sedating at higher doses (but it won't knock you out cold like, say, Zyprexa).
Either one could really help with depression.
BTW, even their delivery methods are fancy, when you take them it's really important to follow the directions, otherwise they won't work.
The Saphris pill needs to fully dissolve under your tongue and you can't eat or drink for at least 10 minutes after taking it. Try not to swallow too much either.
Geodon has to be taken with a high calorie snack / meal (at least 500 calories), which can be a pain. But.. potentially really worth it.
Jeez.
poster:klein
thread:1064708
URL: http://www.dr-bob.org/babble/20140419/msgs/1064753.html