Posted by Louisiana Sportsman on April 19, 2014, at 16:46:04
In reply to Is Viibryd or Brintellix 'energizing'??, posted by mrm36014801 on April 19, 2014, at 10:18:39
> Hello.
>
> My diagnosis has always been major depression and the primary symptom I suffer from is a lack of energy, a sort of enervated fatigue.
>
> Can anyone say if either Viibryd or Brintellix are "energizing" or "activating" (as opposed, to say, "sedating)?
>
> Thank you.
>
>I am disqualified to deliberate vilazodone [Viibyrd (Forrest)]; contrary, au courant is Day 46 of vortioxetine [Brintellix (Lundbeck)] 1TPOQAMCF; Days 1-29, I administered 10mg., and for the past 17 days, 20mg. I can felicitously share my introduction to vortioxetine.
I have not experienced any aggrandizement of sedation since initiation. Due to 5-HT3 antagonism, there is a negligible release of histamine (sedating neurotransmitter), but it seems to be off set by the concomitant dopamine and norepinephrine release.
In terms of activation, I generally prefer for my medications to be energizing as well. My prior ADs were Zoloft (most DA release of the SSRIs) and Effexor/Pristiq (NE reputake inhibition). Antidepressants, besides MAOIs, bupropion (Wellbutrin) and possibly NE heavy desipramine, are generally not something someone takes for the energizing effects.
One of my PDOC's main concerns when prescribing Brintellix was possible sedation due to my treatment resistant bipolar anergic depression and ADHD. She said it would not likely be a factor she was right. If anything, it is an activating AD since I am able to take in the morning (I prefer to take all my medication in the morning, if reasonable), and it has treated me well.
To elucidate, I rank Brintellix among the ADs I've been on. I put wayy too much thought into this, by the way. :D
Zoloft: 8.1/10
Wellbutrin XL 450mg. (Aplenzin 522mg.): 6.0/10
Pristiq 50mg. (Effexor XR 75mg.): 6.7/10
Brintellix: 8.9/10Verdict: Neither sedating, not activating unless you want to count relief which translates to more activity. A good AD, but I suggest:
Try Brintellix only after you have failed a proven SSRI and two other antidepressants from two different classes. If an AD is tolerated, then that AD should be augmented with an atypical antipsychotic before trying Brintellix. Something like: Cymbalta -> Paxil -> Lexapro + Abilify AND then Viibyrd or Brintellix can be justified, and I would still hypocritically recommend a researched AD instead.
Good luck!
poster:Louisiana Sportsman
thread:1064493
URL: http://www.dr-bob.org/babble/20140419/msgs/1064505.html