Posted by Louisiana Sportsman on April 10, 2014, at 13:37:52
In reply to Re: Brintellix vs Lexapro, posted by porkpiehat on April 10, 2014, at 12:28:31
I know I haven't wrote my comprehensive report yet, but I will get to it!
If you're trying to discern the difference between Viibyrd (vilazodone) and Brintellix (vortioxetine), perhaps I can shed some light?
Vilazodone shares serotonin reputake inhibition and 5-HTa partial agonism with Brintellix, but that's about it. This is what makes it the "Buspar" of AD's. It's also listed has sharing 5-HTd receptor antagonism, but in the one study that showed this-- the effect was so negligible that a ki value was not determined; therefore, it is safe to assume it does not contribute to its mechanism of action compared to vortioxetine's 54nm.
Brintellix (vortioxetine), unlike Viibyrd also does:
5-HT1A receptor high-efficacy partial agonist/near-full agonist Ki = 15 nM, IA = 80%
5-HT1B receptor partial agonist Ki = 33 nM
5-HT1D receptor antagonist Ki = 54 nM
5-HT3A receptor antagonist Ki = 3.7 nM
5-HT7 receptor antagonist Ki = 19 nM5-HT1a as well as 5-HT1b agonists have been termed serenics because of their selective ability to inhibit aggressive behavior without sedation in rats and mice. The 5-HT1a is the prototypical receptor involved with Buspar.
5-HT1d antagonists act on the central nervous system, and affect locomotion and most key: anxiety.
5-HT3 receptor antagonists, including those at the a subtype, may have potential anxiolytic, antidepressant, and cognitive effects.
5-HT7 receptor antagonists may be involved in mood regulation, suggesting that they may be useful in the treatment of depression. There is also evidence that they increase cognition.
Worth mentioning also is vortioxetine's 46nm affinity at b1 adrenergic_receptor (which may contribute to side effects) and negligible NET blockade.
Both are novel ADs, sure, but Brintellix significantly differs from Viibyrd.
poster:Louisiana Sportsman
thread:1063866
URL: http://www.dr-bob.org/babble/20140328/msgs/1063966.html