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Making a few med changes; I would like some input

Posted by LouisianaSportsman on April 5, 2014, at 21:24:24

I feel like I can use this place a diary for my med changes, but I get a lot of benefit from this place.

I had my last PDOC appointment Monday and my current medication regiment is now the following:

Adderall IR (amphetamine salts) 60mg.;
Aplenzin (bupropion hydrobromide) 174mg.;
Brintellix (vortioxetine) 20mg.;
Lamictal (lamotrigine) 200mg.;
Latuda (lurasidone) 60mg.;
Nuvigil (armodafinil) 250mg.;
Neurontin (gabapentin) 1,200mg.;
Trokendi XR (topiramate) 200mg.
Xanax XR (alprazolam) 1.5mg.

We increased the Brintellix dosage to 20mg. from 10mg. and she reduced Aplenzin down to 174mg. from 522mg. with instructions for me to go off of it cold turkey this month. We added Xanax XR.

We thought that it'd be best to remove bupropion from the regiment. Bupropion is a strong CYP2D6 inhibitor that interferes with Brintellix. Also, I believe that bupropion makes my amphetamine salts weaker due to reuptake inhibition vs. releaser and I've read literature that supports that bupropion does indeed make the effects amphetamine weaker and vice versa-- that amphetamine blocks the positive effects of bupropion. I think it's best to cease bupropion.

My PDOC said that she'd be open to any ideas I might have to replace the Aplenzin so I was thinking about nortriptyline or desipramine. I am also open to adding another mood stabilizer such as Oxtellar XR.

Other ideas?

Also still having some trouble with anxiety. My PDOC is hesistant to increase my gabapentin dosage because she knows of my abuse of gabapentinoids. Xanax XR is working OK, but I can see myself having some problems with abuse, just like I had a problem with abusing Lyrica. Lyrica, however, was much more abusable. I don't see myself paying people to go to the doctor to get Xanax for me like I did with the Lyrica. I just don't want to have the temptation around every single month. Thoughts on:

Gabitril
Prazosin
Baclofen
Pindolol ?


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poster:LouisianaSportsman thread:1063729
URL: http://www.dr-bob.org/babble/20140328/msgs/1063729.html