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Re: 7 days on Brintellix » SLS

Posted by phidippus on February 26, 2014, at 17:24:31

In reply to Re: 7 days on Brintellix » phidippus, posted by SLS on February 25, 2014, at 5:59:21

It also does all this:

Serotonin transporter (SERT) blocker (i.e. serotonin reuptake inhibitor (SRI)) Ki (binding affinity) = 1.6 nM, IC50 = 5.4 nM
Norepinephrine transporter (NET) blocker Ki = 113 nM
5-HT1A receptor high-efficacy partial agonist/near-full agonist Ki = 15 nM, IA = 80%
5-HT1B receptor partial agonist Ki = 33 nM
5-HT1D receptor antagonist Ki = 54 nM
5-HT3A receptor antagonist Ki = 3.7 nM
5-HT7 receptor antagonist Ki = 19 nM

I'm hitting day 12 on it - 3rd day at the 20 mg dose and I feel nifty. Its like my brain is opening up.

Eric


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URL: http://www.dr-bob.org/babble/20140214/msgs/1061390.html