Posted by poser938 on January 27, 2014, at 4:50:12
In reply to Re: nurse admits anti psychotics treat only pos sympto, posted by Christ_empowered on January 27, 2014, at 3:36:43
Cyproheptadine with its Serotonin antagonism has also been shown to help improve negative symptoms.
I hope this link works on regular computers. I'm on a tablet and some of my links are different.
http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2710.1999.00197.x/abstract
Summary
Objective: There is growing interest in investigating the role of 5-HT receptors in the physiopathology of schizophrenia in particular the negative symptoms. Indeed, newer atypical antipsychotics which interact with 5-HT receptors are more effective in the treatment of negative symptoms compared to typical neuroleptics. We undertook a trial to investigate whether the combination of haloperidol with cyproheptadine, a relatively safe serotonin-blocking agent was more effective than haloperidol alone.Methods: Thirty patients who met the DSM IV criteria for chronic schizophrenia completed the study. Patients were allocated in a random fashion, 15 each to haloperidol 30 mg/day plus cyproheptadine 24 mg/day and haloperidol 30 mg/day plus placebo.
Results: Although both protocols significantly decreased the positive and negative symptom score over the trial period, the combination of haloperidol and cyproheptadine showed significant superiority over haloperidol alone in the treatment of the negative symptoms.
Conclusion: Cyproheptadine is a relatively safe compound and may be of therapeutic benefit in treating negative symptoms of schizophrenia in combination with typical neuroleptics. However, a larger study to comfirm our results is warranted.
poster:poser938
thread:1059582
URL: http://www.dr-bob.org/babble/20140123/msgs/1059624.html