Posted by Willful on January 24, 2014, at 13:06:58
In reply to Re: Willful's suggestion / Dopamine agonist?, posted by Snell on January 24, 2014, at 10:08:38
It's not like any other AD but seems to have anti-depressant andaxiolytic effects as well--. So far its effects aren't really understood but are thought to be dependent on its glutamate antaonism.
From:
"Review of the Use of the Glutamate Antagonist Riluzole in Psychiatric Disorders and a Description of Recent Use in Childhood Obsessive-Compulsive Disorder" (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958461/)~~~"Riluzole inhibits the release of glutamate at the presynaptic nerve cell terminus, most likely by blockade of voltage-gated sodium channels, and this effect may be achieved at low riluzole concentrations (demonstrated most recently by Urbani and Belluzzi 2000). It also likely reduces glutamate neurotransmitter vesicle fusion with the presynaptic cell membrane, either directly by opening voltage-gated calcium channels (Wang et al. 2004) or indirectly by altering G-proteinmediated signaling (Huang et al. 1997). Riluzole's effects on potassium channels have also been measured, but possibly not at clinically meaningful riluzole concentrations (Ahn et al. 2005; Mathie and Veale 2007).
Downstream effects of riluzole have been noted as well, but clinical significance remains unclear. These effects are stimulation of growth factor synthesis, including brain-derived neurotrophic factor (Fumagalli et al. 2006), and promotion of neuritogenesis, neurite branching, and neurite outgrowth (Shortland et al. 2006)."
Emsam.
Abilify
Provigil
Rilutek
poster:Willful
thread:1058262
URL: http://www.dr-bob.org/babble/20140123/msgs/1059406.html