Posted by mogger on December 13, 2013, at 11:18:42
In reply to Re: Treating Depression via the Immune System » Mogger, posted by SLS on December 13, 2013, at 6:40:28
Scott,
Very interesting thanks. I take both NAC and Lamictal both of which have really helped my OCD and Lamictal was the first medication to stop my treatment resistant stretch of 10 years. I seem to do well with glutamate modulators. If minocycline has such antiglutamatergic properties I wonder if it would benefit OCD as glutamate is now being more recognized in OCD sufferers like myself? I saw your post about Glycine for OCD and I saw an interesting description of it that I shall cut and paste here. What do you think? I have seen contributors say Glycine can cause depression so I am interested yet timid to try it. I will talk to my pdoc about minocycline. Luckily he is very open minded and supportive. Hope you are doing well.
Supplemental use of glycine at levels of 1 to 3 grams per day is useful in the treatment of certain forms of bipolar depression (manic depression). Some individuals have an inborn error of glycine metabolism, which means that increased glycine intake can result in elevated glycine levels in the blood that manifest themselves as severe mental retardation in infants susceptible to this condition. This is a very rare genetic metabolism problem, but should be evaluated in any individual who is going to be supplemented with glycine.
Return to top
Method of Action
Glycine serves as a neuroinhibitory neuromodulator in the central nervous system and works along with gamma-amino butyric acid and taurine. It relates to hyperexictability of CNS neurons, thereby depleting them of potassium and chloride and reducing their ability to be stimulated. Glycine is also used in the biosynthesis of hemoglobin, which is very important in maintenance of proper red blood cell integrity and oxygen carrying capacity. Glycine can also be methylated to dimethylglycine (DMG), which is part of the one-carbon pathway that allows for the donation and acceptance of methyl groups. The one-carbon pathway is extremely important for the synthesis of steroids such as the androgenic and estrogenic hormones as well as cortisone-like hormones.
Glycine serves as a neuroinhibitory neuromodulator in the central nervous system and works along with gamma-amino butyric acid and taurine. It relates to hyperexictability of CNS neurons, thereby depleting them of potassium and chloride and reducing their ability to be stimulated. Glycine is also used in the biosynthesis of hemoglobin, which is very important in maintenance of proper red blood cell integrity and oxygen carrying capacity. Glycine can also be methylated to dimethylglycine (DMG), which is part of the one-carbon pathway that allows for the donation and acceptance of methyl groups. The one-carbon pathway is extremely important for the synthesis of steroids such as the androgenic and estrogenic hormones as well as cortisone-like hormones.
Glycine serves as a neuroinhibitory neuromodulator in the central nervous system and works along with gamma-amino butyric acid and taurine. It relates to hyperexictability of CNS neurons, thereby depleting them of potassium and chloride and reducing their ability to be stimulated. Glycine is also used in the biosynthesis of hemoglobin, which is very important in maintenance of proper red blood cell integrity and oxygen carrying capacity. Glycine can also be methylated to dimethylglycine (DMG), which is part of the one-carbon pathway that allows for the donation and acceptance of methyl groups. The one-carbon pathway is extremely important for the synthesis of steroids such as the androgenic and estrogenic hormones as well as cortisone-like hormones.
Glycine inhibits glutamine synthetase, thereby blocking the formation of glutamine from glutatmate. It may, therefore, have some adverse impact upon ammonia detoxification.This was taken from:
http://www.springboard4health.com/notebook/proteins_glycine.html
poster:mogger
thread:1055921
URL: http://www.dr-bob.org/babble/20131209/msgs/1056059.html