Posted by ed_uk2010 on December 4, 2013, at 3:31:06
In reply to Re: how did I induce akathisia? » ed_uk2010, posted by g_g_g_unit on December 3, 2013, at 23:57:28
>do you think that Prazosin could help? clonidine was actually the most effective anti-akathisia drug I've tried to date, but the sedating effects wear off in about 2 days and thereafter it becomes stimulating (messy receptor affinity, I think). there's no guanfacine available here, so I've been looking for stuff that might work similarly to clonidine.
I was wondering about clonidine but didn't suggest it because you were on a beta blocker. Clonidine is a bit of an odd one. It seems to change people's emotions, flat at first followed by intensified emotions later (sometimes). That's my impression anyway, probably why both depression and euphoria are listed as side effects.
The muscle relaxant tizanidine is related to clonidine and might help. I looked for it on the Australian PBS yesterday but couldn't find it. Perhaps it's available but not covered? I suspect not though. I don't know how it works in Aus. You could ask at the pharmacy perhaps. You do have baclofen, but it's really more appropriate for severe muscle spasticity in MS and spinal disease, I don't think it would be appropriate.
I really have no idea about prazosin in your case. In psych, it seems most useful for nightmares in PTSD. It might produce some sedation perhaps? I couldn't find any articles on MedLine.
Now I did have one new idea. The drug cyproheptadine (Peractin). It's a unusual antihistamine which blocks certain serotonin receptors. It's been used in akathisia, migraine, insomnia and (formerly) for allergies. It's listed on the PBS as a restricted benefit, whatever that involves. The usual side effect is drowsiness. It's not very anticholinergic. I know several people on p-babble have taken it for various conditions, especially insomnia.
Have you improved at all over the last few days?
poster:ed_uk2010
thread:1055049
URL: http://www.dr-bob.org/babble/20131115/msgs/1055400.html