Posted by Lamdage22 on November 17, 2013, at 9:38:09
In reply to Re: Help for Schizo-Affective please. » Lamdage22, posted by phidippus on November 16, 2013, at 14:15:48
Yes, but on one website i found that Lamictal and Gabapentin (nmda antagonists) are good against schizophrenia and that Glutamate (a Nmda agonist) is BAD for schizophrenia. It doesnt seem to be THAT easy.
I will see where NAC takes me. The response is very strong on day number 2! WOW
> Over the past few years, attention has been focused on the glutamatergic system involving agents that block N-methyl-d-aspartate or NMDA. Glutamic acid is the major excitatory neurotransmitter in the brain involving 40% of all synapses. Two street drugs, PCP (angel dust) and ketamine (the date rape drug) are known to cause behavior that closely resembles that of schizophrenia. These drugs block the N MDA receptors. In fact, the psychosis induced by both PCP and ketamine very closely resemble schizophrenia because they not only produce positive symptoms but also the negative symptoms and cognitive deficits that are so resistant to treatment in schizophrenia.
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> Post mortem evaluations of the brains of people with schizophrenia have shown that they have fewer NMDA receptors than people who do not have the disease. Both glycine and d-serine (NMDA agonists) have been found to be decreased in both the blood and cerebrospinal fluid of people with schizophrenia compared to controls. This has all led to the hypothesis that people with schizophrenia have too little NMDA and that is one cause of some of the symptoms of the disease particularly the negative symptoms and the cognitive deficits.
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> This knowledge has lead to a number of investigations evaluating the effect of various agents that will increase the amount of NMDA in the brains of those with schizophrenia
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> Eric
Schizo-affective
Seasonal-Affective
Social Anxiety
some PTSD
some Inattentive ADS
300 Seroquel, 1200 Acetylcystein
40-50 mg Parnate
Contemplated: Prazosin for nighmaires
poster:Lamdage22
thread:1054471
URL: http://www.dr-bob.org/babble/20131115/msgs/1054525.html