Posted by doxogenic boy on October 29, 2013, at 17:46:59
In reply to Re: Pubmed Article Benzos and Melatonin, posted by Phillipa on October 28, 2013, at 23:27:25
> Looks like you also must take melatonin with the luvox doesn't it?
To me it looks like you should avoid taking fluvoxamine and melatonin together.
http://www.ncbi.nlm.nih.gov/pubmed/15744215
Quote from the link above:
CNS Spectr. 2001 Jun;6(6):511-3.
Circadian rhythm sleep disorders as a possible side effect of fluvoxamine.
Hermesh H, Lemberg H, Abadi J, Dagan Y.
SourceOutpatients Department and the Anxiety Disorders and Behaviour Therapy Unit, the Geha Mental Health Center, Rabin Campus, Petach-Tiqva, Israel.
AbstractSleep problems, day somnolence, and fatigue as a result of psychotropic drugs are very common. Psychiatrists usually consider these effects a result of insomnia and treat them by prescribing sleeping pills or other benzodiazepine agents. We describe here 10 cases of circadian rhythm sleep disorders (CRSD)--and not merely insomnia--as a possible side effect of fluvoxamine (FVA). Two other serotonin reuptake inhibitors, fluoxetine and clomipramine, did not induce CRSD in any of these 10 patients. We speculate that FVA-induced CRSD is caused by the effect of FVA on serotonin and melatonin levels in the central nervous system. CRSD as a side effect of FVA can be treated by replacing the suspected FVA or adding melatonin to a beneficial FVA treatment. Thus, it is important to be aware of possible iatrogenic CRSD in order to treat appropriately. Prospective studies are needed to confirm our observation and to study the influence of other psychotropic drugs on sleep-wake schedule.
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http://www.ncbi.nlm.nih.gov/pubmed/11270913
Quote from the link above:J Clin Psychopharmacol. 2001 Apr;21(2):167-74.
Differential effects of fluvoxamine and other antidepressants on the biotransformation of melatonin.
Härtter S, Wang X, Weigmann H, Friedberg T, Arand M, Oesch F, Hiemke C.
SourceDepartment of Psychiatry, University of Mainz, Germany.
AbstractMelatonin, the predominant product of the pineal gland, is involved in the maintenance of diurnal rhythms. Nocturnal blood concentrations of melatonin have been shown to be enhanced by fluvoxamine, but not by other serotonin reuptake inhibitors. Because fluvoxamine is an inhibitor of several cytochrome P450 (CYP) enzymes, the authors studied the biotransformation of melatonin and the effects of fluvoxamine on the metabolism of melatonin in vitro using human liver microsomes and recombinant human CYP isoenzymes. Melatonin was found to be almost exclusively metabolized by CYP1A2 to 6-hydroxymelatonin and N-acetylserotonin with a minimal contribution of CYP2C19. Both reactions were potently inhibited by fluvoxamine, with a Ki of 0.02 microM for the formation of 6-hydroxymelatonin and 0.05 microM for the formation of N-acetylserotonin. Other than fluvoxamine, fluoxetine, paroxetine, citalopram, imipramine, and desipramine were also tested at 2 and 20 microM. Among the other antidepressants, only paroxetine was able to affect the metabolism of melatonin at supratherapeutic concentrations of 20 microM, which did not reach by far the magnitude of the inhibitory potency of fluvoxamine. The authors concluded that fluvoxamine is a potent inhibitor of melatonin degradation. Because this inhibitory action is also found in vivo, fluvoxamine might be used as an enhancer of melatonin, which might offer new therapeutic possibilities of fluvoxamine.
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http://www.cpnhelp.org/another_reason_to_take_meExcerpt from the article above:
Fluvoxamine (Luvox), an antidepressant, is known to increase natural melatonin production and it may also increase blood levels of melatonin if it is taken at the same time as melatonin supplementsi. If fluvoxamine and melatonin are taken together, the risk for side effects of melatonin may be increased.
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http://www.dr-bob.org/babble/20080412/msgs/823044.htmlExcerpt from the message above:
A molecule related to fluoxetine, fluvoxamine (Luvox) naturally increases blood levels of melatonin. When fluvoxamine and melatonin are taken at the same time, blood levels of melatonin are significantly higher than if the melatonin were taken by itself. The result of this interaction is an increase in melatonin side effects (eg. headache, nausea, and increased drowsiness). Whether this results in any real danger (in most cases) is doubtful, although the literature does not recommend taking melatonin and fluvoxamine together.The drug interaction between fluvoxamine and melatonin is probably due to fluvoxamine's inhibition of the cytochrome P450 system (CYP); specifically CYP1A2 and CYP2C9 isoenzymes.
End quote.- doxogenic
Earlier TRD/anxiety
300 mg tianeptine, 6 X 50 mg successfully since Oct 2009
20 mcg liothyronine
40 mg escitalopram
100 mg trimipramine
50 mg agomelatine
600 mg quetiapine
poster:doxogenic boy
thread:1053103
URL: http://www.dr-bob.org/babble/20131025/msgs/1053336.html