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Re: Amantadine

Posted by antennastoheaven on September 4, 2013, at 8:51:05

In reply to Amantadine, posted by brynb on August 31, 2013, at 15:48:42

> Nuvigil also makes me anxious and a bit unstable. I've taken Provigil before with some success, but it's quite expensive. With both Nuvigil and Provigil, when I stop taking them, I get that stimulant "crash."

Some people do not respond well to modafinil/armodafinil. There is at least one study that links modafinil response to genetics. I have found both drugs to be marginally more effective than caffeine, but not nearly as effective as amphetamines. One time I took modafinil and fell asleep about an hour later! I have noticed changes in behavior when on these drugs. I am usually less talkative than baseline, which usually isn't a big deal. More troubling, I am more likely to act like I am annoyed or aggravated, without actually feeling the change in mood I normally would.

According to SNPedia[1], a SNP has been linked to modafinil response and those with a specific genotype do not have much of a response to the drug: "rs4680(G;G) carriers deprived of sleep respond quite well to 2x 100mg modafinil in terms of improved vigor and well-being, and maintained baseline performance with respect to executive functioning, whereas rs4680(A;A) individuals barely responded to the drug at all." Per 23andMe, I have AG, which according to the study abstract[2] is supposed to be somewhere in between in effectiveness. I don't have access to the study and I probably wouldn't understand it if I did.

[1] http://www.snpedia.com/index.php?title=Rs4680
[2] http://www.ncbi.nlm.nih.gov/pubmed/19037200?dopt=Abstract

 

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URL: http://www.dr-bob.org/babble/20130828/msgs/1050133.html