Posted by andrewb on August 26, 2013, at 10:23:05
In reply to One more question..., posted by neo on August 23, 2013, at 10:59:13
Okay, we are in a swamp of uncertainties aren't we and forced to make decisions. Here goes.
To be clear amisulpride can and does normally provide a consistent mood benefit to responders, possibly via 5HT-7 antagonism (note: some other low dose antipsychotics share this 5HT-7 antagonism).
The energy effect, however, I haven't known or heard to be enduring. If it is an amphetamine like effect, it MIGHT be preserved by combining with a partial NMDA antagonist like memantine.
I consider the sedation effect a separate action from the energy effect, rather than part of a continuum. If a 12.5gm dose sometimes but not always sedates you, you can use a gram scale to provide yourself with accurate dosages for dosages of 12.5 grams and smaller.
For the sake of perspective, lets list why ami.s affect has been so unpredictable for you: 1) varying doses of amisulpride, 2) varying dosing schedules of ami, 3) interactions with a benzo., and 4) development of dopaminergic system tolerance(s).
A 5th factor should be added, I think, if I'm understanding the research correctly. That is, changes induced on your system by inflammation and stress (both physiological and psychological). Energizing effects in particular may be hard to sustain under conditions of high stress and inflammation in the brain. Personally, I ASSUME my brain is prone to high stress and inflammation, and, in response, make lifestyle choices (e.g. short burst aerobic exercise that emphasizes 'FLOW') and supplement choices accordingly. The goal is to provide a more stable platform to work off of. For example I supplement with a high dose fish oil stabilized against oxidation, and a brain available form of curcumin (Theracurmin) consisting of water soluble nano particles.
For sleep and anxiety; melatonin (time released, 300 micrograms, no higher!), and Bacopa (e.g. Bacopa Gold brand) can be helpful.
For an alerting affect, sublingual uridine monophosphate helps many. It also encourages neurogenesis.
I hope this information is helpful and best wishes.
poster:andrewb
thread:1048097
URL: http://www.dr-bob.org/babble/20130730/msgs/1049739.html