Posted by creepy on August 14, 2013, at 23:29:48
In reply to Atypical APs and depression, posted by orbital on August 14, 2013, at 20:20:04
The AAPs are serotonin receptor antagonists too. Some of these receptors are implicated in mood, sleep, motivation.
I used to think prescribing an AAP for depression was like hitting a nail with a sledgehammer, but now im not so sure.
If you want to try a serotonin receptor antagonist but are afraid of the antipsychotics, you could try trazodone (at antidepressant doses), nefazodone or a few of the TCAs like nortriptyline and amitriptyline.
I think 5ht-2c receptor antagonism may help with the apathy from SSRIs. Something about dopamine regulation via this receptor?
poster:creepy
thread:1049029
URL: http://www.dr-bob.org/babble/20130730/msgs/1049053.html