Posted by jedi on April 18, 2013, at 23:11:59
In reply to Re: nardil tolerance and ensuing cognitive problems, posted by rose45 on April 18, 2013, at 18:04:38
Hi Rose, we are similar in a lot of ways. I have been on Nardil for most of 15 years. No combination of other meds (45+) has ever worked for me. I have stopped Nardil at least a half dozen times over the years, the major depression has always returned. I am lucky in that going back on Nardil has always stopped the major depression. I have had a level of dysthymia since my teenage years, and this has never gone away. But at least Nardil stops the major depression for me.
I was hypomanic, maybe manic, the first time I used Nardil in 1998. I made some very bad financial decisions at the time. Luckily, the mania went away, and has never returned; even after restarting Nardil after 9 months off.
I have some memory impairment also, I blame this mostly on the concurrent use of of clonazepam. I am currently in a very slow taper off the benzo, down to .5 mg per day.
I have been on every medication that you mention in your posts. I have taken Seroquel with Parnate. Unfortunately, for me, Parnate caused a rare spontaneous hypertensive reaction. So that trial ended. I have also used Nortriptyline in combination with Nardil. This can work well in some people, but for me, it did not really add very much.
Seroquel is an atypical antipsychotic, which in low doses, can work very well for sleep. Your Dr. is right in that it can help stop a med induced hypomania or mania. I believe that atypical depression does lie somewhere on the bipolar spectrum, and that is why we can be vulnerable to the med induced mania. Just my opinion. It is strange to me why the mania has never returned after it hit me when first starting Nardil. I'm wondering if the formula change in 2003? had something to do with it?
I am so sorry that the Nardil quit working for you. The MAOIs are a category of meds that can work for major depression when all others fail. Good luck with the Parnate. I know how painful major depression is. Worst pain I have ever had, including all physical pain!
Good luck and be well,
Jedi
Jedi
Treatment resistant, atypical, double depression with social anxiety.
Nardil + clonazepam
poster:jedi
thread:1042294
URL: http://www.dr-bob.org/babble/20130408/msgs/1042345.html