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Re: PARNATE high-dose - Vanvog

Posted by Tyrannosaur on April 12, 2013, at 1:15:18

In reply to Re: PARNATE high-dose strategy and diminishing returns, posted by vanvog on April 11, 2013, at 22:04:26

> I'm familiar with the concept of diminishing returns, I would however like to know what made those people who pursued a high-dose strategy stop upping the dose. Let's say I get a 10% (or 5%) improvement on my symptom(s) by pushing the dose another 20mg further, I would do it if cost is no concern and the side-effects don't get worse by doing so.

Perhaps those people accidentally read this;

http://books.google.se/books?id=KDOeIldGWxQC&pg=PT293&lpg=PT293&dq=phenelzine+2mg/kg&source=bl&ots=QIl0P-M3zx&sig=ZCXArz6NZUr1SgA9kDPF0w6egWs&hl=en&sa=X&ei=oaFnUaK9H4mG4AT054GQDA&redir_esc=y

"Tranylcypromine
- >1 mg/kg associated with toxicity
- 170 mg has caused a fatality"

http://curriculum.toxicology.wikispaces.net/Monoamine+oxidase+inhibitors+%28Detail%29

"More than 1 mg/kg is likely to be a significant poisoning"

Pursuing symptom relief from very high doses might produce the opposite effect. But people have done it before, although would being on very high doses of TCP long-term be a viable option?

Just be careful and be well.


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poster:Tyrannosaur thread:1042019
URL: http://www.dr-bob.org/babble/20130408/msgs/1042070.html