Posted by linkadge on April 1, 2013, at 19:47:27
In reply to Re: Long-term antidepressant studies, posted by Scars R. Stories on April 1, 2013, at 17:21:58
Look, I don't know what 'studies' you are referring to. Data can be analyzed in a million different ways to reach different conclusions.
Thats why effexor > sertaline > citalopram > effexor
One study sponsored by GSK showed that wellbutrin was excellent for anxiety. That doesn't mean that this is true.
Wellbutrin is a good stimulant like medication for atypical depression. Atypical depression is more common in western cultures due to the general crisis with overconsumption, obesity and insulin resistance. This combined with the typical western focus on workaholsim would naturally produce a market for stimulant like antidepressants. In fact, wellbturin will substitute for cocaine and methamphetamine in certain animal models of stimulant reinforcement.
The type of depression we have today is more a result of our fast paced lifestyles and poor nutrition. Classic depression, was almost always described in terms of insomnia, agitation, anxiety, weight loss etc.
My grandfather had many depressive epsisodes in his life. In his 80's they gave him wellbutrin and it had him pacing nonstop for days and nights in a row. Finally they went back to doxapin (which had worked for him in the past). Doxapin has a similar profile to mirtazapine (high h1 and 5-ht2 antagonism).
Mirtazapine has been shown in a few studies to have a faster onset of activity than SSRIs or SNRIS. But again, 'depression' is an incredibly heterogeneous disorder. I have a friend that responded well to fluoxetine. Also, his seizure frequency dropped (an additional therapeutic effect of fluoxetine) from about 3 a day to 1 a week. AFAIK, epilepsy is not terribly responsive to placebos.
When I am depressed. I don't need an "antidepressant". I need something that will help me sleep and eat, and my body can do the rest to heal itself.
Linkadge
poster:linkadge
thread:1041418
URL: http://www.dr-bob.org/babble/20130322/msgs/1041511.html