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Alcohol and benzo cross tolerance

Posted by joe schmoe on February 18, 2013, at 16:48:37

I am curious as to why klonopin has lost a lot of its efficacy for me lately, after being on it for over ten years. I was wondering if it was related to my acquiring a daily drinking habit due to my discovery of craft beer.

I have seen some people elsewhere state with great confidence (but no citations to studies) that drinking alcohol can cause a cross-tolerance to develop to benzos, reducing their efficacy. It is hard to get good information on benzo tolerance in general, some doctors seem to think benzo tolerance is inevitable while others seem to think that people with anxiety can take them long-term with no tolerance developing.

Does anyone know if there is a scientific proof behind this idea of alcohol causing benzo tolerance, other than "they both affect GABA in some way."


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poster:joe schmoe thread:1038353
URL: http://www.dr-bob.org/babble/20130205/msgs/1038353.html